Study of non-carcinogenic genotoxic drugs (NCGDs) might reveal three medical principles

Aetiology is the study of the causes or origins of diseases. A thorough understanding of aetiology is vital for all diseases’ prevention, diagnosis, and treatment. Further study of non-carcinogenic genotoxic drugs (NCGDs) might reveal three medical principles, the first one is abnormal gene expression patterns that exist in all internal diseases and might be considered as a unified cellular aetiology for all diseases; the second one is changing abnormal gene expression patterns in the cells associated with all diseases that is named as unified drug action for all drug treatments; the third one is a unified mechanism of action of all drugs that could be used to explain the mechanism of action of every drug. Both internal and external disease-causing factors could cause abnormal 3D genome structure in related cells that causes abnormal gene expression patterns in related cells, which leads to clinical manifestations including subjective symptoms and physical signs. Changing abnormal gene expression patterns by NCGDs or second-class NCGDs is the essence of all drugs’ action. NCGDs have powerful effects on alteration of gene expression patterns, and second-class NCGDs might have weak effects but are necessary for treating some diseases. If the three medical principles are proven true, focussing on these three medical principles are vital important in developing drugs and improving consequences of all diseases.