Non-Carcinogenic Genotoxic Drugs (NCGDS) and cancer prevention and treatment

Based on our carcinogenesis theory, cancer cell formation might be a cell transformation, that is a normal cell type being transformed into cancer-cell type. Cancer cell’s chromatin configuration has been named as cancer- associated chromatin configuration (CACC) that could be cancer-cell-type chromatin configuration. Under long-time carcinogen exposure, a cell that may have many gene mutations but without CACC will not be cancerous. Only cells that have CACC are cancerous. Non-carcinogenic genotoxic drugs (NCGDs) are old drugs that have genotoxicity but are non-carcinogenic when safe dose and course are used or might modulate the expression of many genes through directly or indirectly affecting 3D genome structure. We believe that NCGDs are the best drugs for preventing all viral infections including transmitted viruses and cancer-causing viruses, but also good drugs for preventing and treating cancer. Besides, antioxidants that support anticancer activity belong to NCGDs, indicating that NCGDs might improve immune system. We encourage researchers to use NCGDs as a tool to study 3D genome structure and transcriptome, which will help to rapidly discover good medicines like NCGDs for treating variety of difficult diseases including cancer.