Prevention of all viral infections by Non- Carcinogenic Genotoxic Drugs (NCGDS)

Comparing 1918 Spanish influenza pandemic with 2019 COVID-19 pandemic, people in the both pandemics had no prophylactic drugs for preventing viral infections that contributed to the death toll. No prophylactic drugs in1989 was acceptable because medical science and biotechnology was not good at that time. But in 2019, global biomedical science has advanced to a high level, people still didn’t have prophylactic drugs for preventing COVID-19 infections. The deep reason might be because there is no theory that could help people to find prophylactic drugs for preventing viral infections. In 2020, we first proposed the novel antiviral theory: The reason why a virus can specifically infect its target cells is because the gene expression patterns in the target cells are suitable for viral infection. Alteration of 3D genome structure can change the gene expression patterns in the target cells, reducing susceptibility of the target cells to viral infections. We assumed that non-carcinogenic genotoxic drugs (NCGDs) might change gene expression patterns. NCGDs are old or existing drugs that are non- carcinogenic but might regulate expression of many genes through affecting genome structure. With this knowledge, people can easily find drugs for preventing all viral infections. If our antiviral theory is put into medical practice, there will be no future viral pandemics.