Basic life support (BLS) is a key component of chain of survival. It decreases the chance of mortality. Invented in 1960, CPR is a simple but effective procedure that allows almost anyone to sustain life in the early critical minutes after cardiac and respiratory arrest. The aim of this study to assess the effectiveness of Video assisted teaching program on BLS among Nurses in Apollo Hospitals. The Research approach was Quantitative, pre-test (O1) and post-test (O2) without a control group was used for this study. Convenient Sampling technique was followed and 30 Nurses were selected for this study. Observational Checklist & Structured Questionnaire was used to assess the Knowledge of the Nurses and Video assisted teaching was given after the Pre-test. Data were collected and analyzed which showed, before intervention, 33.33% of the Staff Nurse are having inadequate knowledge score, 56.67% of them having moderate knowledge score and 10% of them are having adequate knowledge. After intervention, none of the Staff Nurse are having inadequate knowledge score, 26.67% of them having moderate knowledge score and 73.33% of them are having adequate knowledge. This study has very high significant at p≤0.001 level.