This study is a descriptive study with a quantitative approach that aims to analyze instrument validity and scientific literacy skill of the third Chemistry Education students in the faculty of teachers and training at the University of Mataram on waste management materials. There are 68 students in this study's sample, with simple random sampling as the technique for collecting the sample. This study's data collection is a test instrument similar to PISA based on scientific literacy analyzed using descriptive statistics. The result of instrument validity from validators (expert lecturers) shows that the average of 79.40% is entirely valid and can be used for measuring scientific literacy skills, but it needs revision. The result of each aspect shows that the average knowledge aspect (60.80%), context aspect (63.30%), competency aspect (66.50%), and attitude aspect (66.30%) so that the scientific literacy skill of third-semester chemistry education students at faculty of teachers and training at the University of Mataram is in enough category (63.30%). This study shows that the scientific literacy skill of chemistry education students at the University of Mataram needs to be improved, so each of the indicators gets a sufficient number and the scientific literacy skill becomes better.