The COVID-19 pandemic has caused significant harm to humanity in recent years. However, there is hope that artificial intelligence (AI) technology can help combat emerging diseases. AI-based generative models can combine datasets to develop drugs for exploring new medical compounds. Deep-learning generative models and molecular modeling tools have been used to identify an effective ligand that terminates the operation of COVID-19 major protease. Additionally, AI can accurately detect disease infections through X-ray, MRI, and CT scans, which is more reliable than the RT-PCR method. Physicians can use an automated deep learning-based application to obtain a thorough and informative report to aid in patient diagnosis. Machine learning and AI applications can help governments and medical experts respond more effectively to pandemics or patients requiring urgent medical attention. In a pandemic such as COVID-19, it is crucial to make rapid and precise clinical decisions to determine the severity of diseases. Although AI technology presents promising advantages, further research is necessary to make it faster and more accurate in providing reliable information.